Eve Montana at 2010-04-11 14:36:30:
What if the protagonist inherited a valuable item from her great-aunt that turns out to be stolen from a couple of hard characters?
Or perhaps upon the great-aunt's death, the protagonist receives a scavenger hunt letter that will eventually lead her to the valuable item the great-aunt had stashed away. She must find this item before the antagonist(s).
Or maybe the protagonist finds old floor plans for a bank that her great-aunt planned on hitting before her death. The protagonist, deeply in debt, decides to enter the family business and knock off the bank.