"It's all right, I'm not drunk. I'm lame."

The Hustler

Maybe not the best or worst, but encapsulates the character most concisely.

Heh... this probably would fall under the category of "worst."

Napoleon Dynamite: [referring to Deb's milk] I see you're drinking 1%. Is that 'cause you think you're fat? 'Cause you're not. You could be drinking whole if you wanted to.

From "Real Genius":

Chris: If there's anything else I can do for you - or to you - please let me know.

Susan: Can you hammer a six inch spike through a board with your penis?

Chris: Um, not right now.

Susan (leaving): A girl's gotta have her standards.

"Lorraine, my density has brought me to you..."
George McFly, Back to the Future

http://www.youtube.com/watch?v=tNGxE6s-59s

Gael García Bernal in THE SCIENCE OF SLEEP:

"I like your boobs. They're very friendly and unpretentious."


Kate Winslet in ETERNAL SUNSHINE:

"Drink up, young man. It'll make the whole seduction part less repugnant."


Richard Griffiths in WITHNAIL & I:

"I mean to have you, boy, even if it must be burglary!"


Laura Dern and Kyle McLachlan in BLUE VELVET:

Sandy: I can't figure out if you're a detective or a pervert.
Jeffrey: Well, that's for me to know and you to find out.

Ron Burgundy: I don't know how to put this but I'm kind of a big deal.
Veronica Corningstone: Really.
Ron Burgundy: People know me.
Veronica Corningstone: Well, I'm very happy for you.
Ron Burgundy: I'm very important. I have many leather-bound books and my apartment smells of rich mahogany.

Will Ferrell in Anchorman



Sandra Bloom: You don't even know me.
Young Ed Bloom: I have the rest of my life to find out.

Ewan McGregor in Big Fish