Bah Bahrbahrossa at 2009-12-03 17:30:47:
Before I comment, let me first say that I am a screenwriter who ASPIRES to get paid, not just to write. My current occupation is SCRIPT READER, so despite my lack of professional success in my desired field, I feel like I can answer you and at least sound legit.
QUESTION: "Is it okay to have the antagonist drive the plotline?"
MY ANSWER: it's possible I interpreted the question differently. No, it's not okay for the antagonist of your script (provided that there is an equally as game PROtagonist) to drive the plotline.
I think what Scott was referring to was different than what you asked. Yes, sure it's okay for protagonists to REACT: most cop movies and chase movies do exactly that...
But as a reader, if the bad guy is the one who really OWNS the story, than A) he needs to have pathos (a la SAVE THE CAT -- which would in turn, make him a PROTAGONIST), or B) he needs to be a protagonist whose revelation at the end proves him to be diabolical (think Verbal Kint).
That's just my two cents and again, I don't know shit about getting my work sold...yet.
Good luck.
Z