Scott at 2016-04-04 18:54:32:
The structure of the narrative is a classic Hero's Journey: The Protagonist receives a Call To Adventure, here in the form of Lipsky's reading of "Infinite Jest," then proposing a Rolling Stone article on Wallace. He departs his home (SEPARATION) and goes on a journey with Wallace. Along the way, Lipsky experiences vicariously what it's like to be a writer of enormous talent as well as a significant questions about what fame can bring (INITIATION). Lipsky and Wallace develop a contentious relationship which resolves itself in the end, and Lipsky flies back home (RETURN). The three meta stages of the Hero's Journey.
Also interesting to note: A road trip in which two disparate characters end up together is one of the oldest narrative constructions in Hollywood history (see It Happened One Night - 1932).
So even though The End of the Tour is bathed in philosophy, psychology, and cultural reflection, its structure is quite traditional in a movie sense.