I kind of jump between the four. Right now I'm finishing a high-concept SEAL team then on to a high concept family action comedy.

I've also got a micro-budget that started out as a short.
Staying flexible is the best thing to do. Oh and don't forget horror.

What are the four quadrants? Excuse my ignorance.

I'm pretty firmly established in the moderate budget action range. I doubt I'll ever write anything that can be a true Indie. If someone gave me lots of money I could easily write a tentpole.

Where are you focusing your spec script energy now?

A moderate budget major studio genre story - in particular, a paranormal mystery thriller with great roles and great themes.

Low on CGI, big on concept, definitely four quadrant. I wouldn't say it's "tentpole" (as I understand "tentpole"), but it is "franchisable" (word?) and I've already set up two sequels.

I'm convinced that, in the hands of the right director (someone with vision and disciplined with money), I've got a moneymaking trilogy here that could be made relatively cheap.

How on earth does one get any idea how much it would cost to produce a given script?

@Ashley: A four quadrant movie refers to a movie that appeals to males, female, young, old demo groups. For more info, here and here.

@Wolf Lahti: You can hire people to budget your script. But to get a general sense of numbers, I suggest you do this: Go to boxofficemojo.com and click through the 50 top grossing movies this year. There should be production budgets listed for each one. In fact, if I have the time, I'll try to put together a list for a GITS post. That way, you can find similar movies to a script you're writing to get a relative scale of cost.