Don't know if you've already got it all planned out, but a recent opening line that really stuck with me is in Michael Clayton. Its really an opening monologue, but still Wilkenson is damn powerful in that speech.

http://www.youtube.com/watch?v=FjTp3MSh-Vw

Thanks, Zeb. We've gotten quite a few suggestions, so I'll probably run with this theme through next week as well. And yes, that opening of "Michael Clayton" is an amazing monologue.